1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide
• CAS No.: 123566-49-4
• Molecular Formula: C₁₇H₂₅F₂N₃O₂S
• Molecular Weight: 373.467
• Mol file: 123566-49-4.mol

Synonyms:1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide

Chemical Property of 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide

There total 4 articles about 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tert-butyl isothiocyanate (590-42-1) + 1-(3,5-difluorobenzyl)-2-(tert-butoxycarbonyl)hydrazine (123566-47-2) → 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide (123566-49-4)

Guidance literature:

In ethyl acetate; for 7h; Heating;

DOI:10.1021/jm00164a051

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide (123566-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / hexane / 0.5 h / Heating

2: 95 percent / H₂ / 10percent Pd/C / methanol / 4.5 h / 2068.6 Torr

3: 65 percent / ethyl acetate / 7 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; hexane; ethyl acetate;

DOI:10.1021/jm00164a051

Reference yield:

3,5-difluorobenzaldehyde (32085-88-4) → 1-(tert-butoxycarbonyl)-2-(3,5-difluorobenzyl)-4-tert-butylthiosemicarbazide (123566-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / hexane / 0.5 h / Heating

2: 95 percent / H₂ / 10percent Pd/C / methanol / 4.5 h / 2068.6 Torr

3: 65 percent / ethyl acetate / 7 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; hexane; ethyl acetate;

DOI:10.1021/jm00164a051

upstream raw materials:

tert-butyl isothiocyanate

1-(3,5-difluorobenzyl)-2-(tert-butoxycarbonyl)hydrazine

t-butoxycarbonylhydrazine

3,5-difluorobenzaldehyde

Downstream raw materials:

1-(3,5-difluorobenzyl)-1,2,4-triazole-5-thione