ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Base Information

Chemical Name:ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate
CAS No.:1300089-41-1
Molecular Formula:C₁₈H₁₆ClN₃O₂S
Molecular Weight:373.863
Hs Code.:

Synonyms:ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

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Chemical Property of ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

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Technology Process of ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

There total 7 articles about ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1300089-88-6
ethyl (5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

: 1300089-41-1
ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: With Lawessons reagent; In toluene; for 4h; Reflux;
DOI:10.1021/jm401088k

Reference yield:

: C₂₉H₂₃ClN₆O₃

: 1300089-41-1
ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate; acetic acid / 24 h / 20 °C

2: hydrogen bromide; acetic acid / 0.5 h / 80 °C

3: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

4: Lawessons reagent / toluene / 4 h / Reflux

With Lawessons reagent; ammonium acetate; hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm401088k

Reference yield:

: 1206716-08-6
[benzotriazol-1-yl(2-(4-chloro-benzoyl)-phenylcarbamoyl)-methyl]-carbamic acid benzyl ester

: 1300089-41-1
ethyl (5-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / methanol / 1 h / 20 °C / Inert atmosphere

2: ammonium acetate; acetic acid / 24 h / 20 °C

3: hydrogen bromide; acetic acid / 0.5 h / 80 °C

4: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

5: Lawessons reagent / toluene / 4 h / Reflux

With Lawessons reagent; ammonium acetate; ammonia; hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm401088k