ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

Base Information

Chemical Name:ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate
CAS No.:1300087-02-8
Molecular Formula:C₂₀H₁₈ClN₅O₂
Molecular Weight:395.848
Hs Code.:

Synonyms:

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Chemical Property of ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

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Technology Process of ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

There total 10 articles about ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₃ClN₆O₃

: 1300087-02-8,1300087-46-0,1300089-33-1
ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium acetate; acetic acid / 24 h / 20 °C

2: hydrogen bromide; acetic acid / 0.5 h / 80 °C

3: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

4: Lawessons reagent / toluene / 4 h / Reflux

5: hydrazine hydrate / methanol / 16 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7: acetic acid / 0.5 h / Reflux

With Lawessons reagent; ammonium acetate; hydrogen bromide; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm401088k

Reference yield:

: 2894-51-1
2-amino-4'-chlorobenzophenone

: 1300087-02-8,1300087-46-0,1300089-33-1
ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: 1,2-dichloro-ethane; dmap / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: ammonia / methanol / 1 h / 20 °C / Inert atmosphere

3: ammonium acetate; acetic acid / 24 h / 20 °C

4: hydrogen bromide; acetic acid / 0.5 h / 80 °C

5: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

6: Lawessons reagent / toluene / 4 h / Reflux

7: hydrazine hydrate / methanol / 16 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

9: acetic acid / 0.5 h / Reflux

With Lawessons reagent; dmap; ammonium acetate; ammonia; hydrogen bromide; hydrazine hydrate; acetic acid; 1,2-dichloro-ethane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm401088k

Reference yield:

: C₁₈H₁₈ClN₅O₂

: 1300087-02-8,1300087-46-0,1300089-33-1
ethyl (6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: acetic acid / 0.5 h / Reflux

With acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm401088k