2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

Base Information

Chemical Name:2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate
CAS No.:1220511-11-4
Molecular Formula:C₂₈H₄₁FN₄O₁₃S₃
Molecular Weight:756.849
Hs Code.:

2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

Synonyms:2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

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Chemical Property of 2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

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Technology Process of 2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

There total 1 articles about 2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220511-10-3
tert-butyl ethyl[(4S)-1-(4-{[(4-fluorobenzyl)amino]carbonyl}-5-hydroxy-6-oxo-1,6-dihydropyrimidin-2-yl)-5-hydroxy-4-methoxypentyl]carbamate

: 124-63-0
methanesulfonyl chloride

: 1220511-11-4
2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; acetonitrile; at 0 ℃; for 0.5h;

Reference yield:

: 1220511-11-4
2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

: 1220511-43-2
C₂₅H₃₃FN₄O₆

Guidance literature:: With sodium hydrogencarbonate; In dimethyl sulfoxide; at 35 - 80 ℃; Industry scale;

Reference yield:

: 1220511-11-4
2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate

: 1220511-12-5
(7S,10S)-10-[(tert-butoxycarbonyl)(ethyl)amino]-2-{[(4-fluorobenzyl)amino]carbonyl}-7-methoxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-3-yl methanesulfonate

: 1220511-13-6
(7S,10R)-10-[(tert-butoxycarbonyl)(ethyl)amino]-2-{[(4-fluorobenzyl)amino]carbonyl}-7-methoxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-3-yl methanesulfonate

Guidance literature:: 2-{(4S)-1-[(tert-butoxycarbonyl)(ethyl)amino]-4-methoxy-5-[(methylsulfonyl)oxy]pentyl}-6-{[(4-fluorobenzyl)amino]carbonyl}pyrimidine-4,5-diyl dimethanesulfonate; With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

With methanesulfonyl chloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;