2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

Base Information

Chemical Name:2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid
CAS No.:338735-94-7
Molecular Formula:C₁₇H₁₉F₃N₄O₇
Molecular Weight:448.356
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3<i>H</i>-diazirin-3-yl)-phenoxy]-butyric acid

Synonyms:2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

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Chemical Property of 2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

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Technology Process of 2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

There total 5 articles about 2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 338735-84-5
L-2-amino-4-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitro-1-phenoxy]butanoic acid

: 338735-94-7
2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

Guidance literature:: With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 12h;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 271252-28-9
4-(1-azi-2,2,2-trifluoroethyl)-1-(2-bromoethoxy)-2-nitrobenzene

: 338735-94-7
2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / KH / dimethylformamide / 24 h / -42 - 20 °C

2: 84 percent / aq. NaOH / ethanol; H₂O / 20 °C

3: dioxane / 1 h / 80 °C

4: 29 percent / CoCl₂; aq. NaOH; Aspergillus genus, acylase enzyme / aq. phosphate buffer / 48 h / 35 - 38 °C / pH 7.4

5: 97 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

With sodium hydroxide; acylase enzyme; Aspergillus genus; potassium hydride; triethylamine; In 1,4-dioxane; phosphate buffer; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/com-00-s(i)90

Reference yield:

: 338735-82-3
DL-2-acetamido-4-[4-(1-azi-2,2,2-trifluoroethyl)-2-nitro-1-phenoxy]butanoic acidd

: 338735-94-7
2-tert-butoxycarbonylamino-4-[2-nitro-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / CoCl₂; aq. NaOH; Aspergillus genus, acylase enzyme / aq. phosphate buffer / 48 h / 35 - 38 °C / pH 7.4

2: 97 percent / Et₃N / dioxane; H₂O / 12 h / 20 °C

With sodium hydroxide; acylase enzyme; Aspergillus genus; triethylamine; In 1,4-dioxane; phosphate buffer; water;
DOI:10.3987/com-00-s(i)90