1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

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Chemical Name:1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline
CAS No.:374633-80-4
Molecular Formula:C₃₀H₂₆N₄O₂
Molecular Weight:474.562
Hs Code.:

Synonyms:1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

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Chemical Property of 1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

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Technology Process of 1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

There total 5 articles about 1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 27794-03-2
2-chloro-5-(4-methoxyphenyl)pyrimidine

: 199678-69-8
1-(2,3-dihydro-5-benzofuranyl)-2,3,4,9-tetrahydro-1H-β-carboline

: 374633-80-4
1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 16h;
DOI:10.1021/jm025545d

Reference yield:

: 55745-70-5
2,3-dihydro-benzofuran-5-carbaldehyde

: 374633-80-4
1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: DIEA / dimethylformamide / 120 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)01036-3

Reference yield:

: 61-54-1
tryptamine

: 374633-80-4
1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: DIEA / dimethylformamide / 120 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)01036-3