27794-03-2 Usage
Description
2-Chloro-5-(4-methoxyphenyl)pyrimidine, a pyrimidine derivative with the molecular formula C11H9ClN2O and a molecular weight of 214.66 g/mol, is a chemical compound that features a chloride and a methoxyphenyl group. It is recognized for its role as a building block or intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds, and is valued for its potential in the development of various drugs and biologically active molecules. Furthermore, it is utilized in research and development activities within the realms of organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
2-Chloro-5-(4-methoxyphenyl)pyrimidine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-5-(4-methoxyphenyl)pyrimidine is employed as a building block in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby supporting agricultural productivity.
Used in Organic Synthesis Research:
2-Chloro-5-(4-methoxyphenyl)pyrimidine is utilized as a research compound in organic synthesis, where it aids in the exploration of new synthetic pathways and the development of innovative chemical reactions. Its presence in these studies is crucial for advancing the understanding of organic chemistry and its applications.
Used in Medicinal Chemistry Research:
2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE also serves as a vital research tool in medicinal chemistry, where it is used to investigate the structure-activity relationships of potential drug candidates. Its unique properties make it instrumental in the design and optimization of biologically active molecules for various therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 27794-03-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,7,9 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 27794-03:
(7*2)+(6*7)+(5*7)+(4*9)+(3*4)+(2*0)+(1*3)=142
142 % 10 = 2
So 27794-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H9ClN2O/c1-15-10-4-2-8(3-5-10)9-6-13-11(12)14-7-9/h2-7H,1H3
27794-03-2Relevant articles and documents
Cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines: Synthesis of hyrtinadine A+
Mosquera, Angeles,Riveiros, Ricardo,Sestelo, Jose Perez,Sarandeses, Luis A.
supporting information; experimental part, p. 3745 - 3748 (2009/07/09)
(Chemical Equation Presented) The palladium-catalyzed cross-coupling reaction of triorganoindium reagents (R3In) with 5-bromo-2- chloropyrimidine proceeds chemoselectively, in good yields, to give 5-substituted-2-chloropyrimidines or 2,5-disubstituted pyrimidines using 40 or 100 mol % of R3In, respectively. Sequential cross-couplings are also performed, in one pot, using two different R3In. This method was used to achieve the first synthesis of the alkaloid hyrtinadine A. The key step was a two-fold cross-coupling reaction between a tri(3-indolyl)indium reagent and 5-bromo-2-chloropyrimidine.
Electronic Effects of Aryl and Heteroaryl Groups on the Rate of Nucleophilic Displacement of Chlorine from 5-Heteroaryl(or Aryl)-2-chloropyrimidines by Piperidine
Allen, David W.,Buckland, David J.,Hutley, Barrie G.
, p. 463 - 467 (2007/10/02)
The kinetics of nucleophilic displacement of chlorine from a series of 2-chloro-5-heteroaryl(or aryl)pyrimidines by piperidine have been studied in order to assess the electronic effects of the 5-substituent.The observed order of reactivity is 5-(1-methyl
