2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

Base Information

Chemical Name:2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone
CAS No.:134079-03-1
Molecular Formula:C₂₀H₃₁BrO₂Si
Molecular Weight:411.454
Hs Code.:

Synonyms:2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

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Chemical Property of 2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

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Technology Process of 2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

There total 4 articles about 2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 134079-24-6
[6-(2-Bromo-benzyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 134079-03-1
2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 16h;
DOI:10.1021/jo00011a009

Reference yield:

: 13747-72-3
ethyl 1,4-dioxa-spiro[4,5]decane-6-carboxylate

: 134079-03-1
2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1) LDA / 1) hexane, THF, 0 deg C, 30 min 2) THF, 0 deg C, 16 h

2: 69 percent / LiBH₄ / diethyl ether / 6 h / 0 °C

3: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h

With dmap; lithium borohydride; triethylamine; lithium diisopropyl amide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00011a009

Reference yield:

: 134079-23-5
6-(2-Bromo-benzyl)-1,4-dioxa-spiro[4.5]decane-6-carboxylic acid ethyl ester

: 134079-03-1
2-(2-Bromobenzyl)-2-<<(tert-butyldimethylsilyl)oxy>methyl>cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / LiBH₄ / diethyl ether / 6 h / 0 °C

2: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h

With dmap; lithium borohydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jo00011a009