13747-72-3

Usage

InChI:InChI=1/C11H18O4/c1-2-13-10(12)9-5-3-4-6-11(9)14-7-8-15-11/h9H,2-8H2,1H3

Upstream product

• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 16493-10-0 2-butyrylcyclohexanone 
• 107-21-1 ethylene glycol 

Downstream Products

• 90862-78-5 (2-oxo-cyclohexyl)bis-(3,5-dimethylphenyl)methanol 
• 4746-93-4 1,4-dioxaspiro[4.5]decane-6-carboxylic acid 
• 854133-07-6 1,4-dioxa-spiro[4.5]decane-6-carbonyl chloride 
• 675868-81-2 8-azabicyclo[3.2.1]oct-3-yl 2-phenylcyclohex-2-enecarboxylate 
• 675868-79-8 (1R,3R,5S)-3-(2-Phenyl-cyclohex-2-enecarbonyloxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 1-chloro-ethyl ester 
• 675868-83-4 methyl 2-[8-aza-3-(2-phenylcyclohex-2-enylcarbonyloxy)bicyclo[3.2.1]oct-8-yl]acetate 
• 675868-95-8 ethyl 2-[8-aza-3-(2-phenylcyclohex-2-enylcarbonyloxy)bicyclo[3.2.1]oct-8-yl]acetate 
• 24927-50-2 2-Hydroxymethyl-1-phenyl-cyclohexanol 
• 5331-08-8 2-(hydroxymethyl)cyclohexanone 
• 24102-01-0 2-phenylcyclohex-2-ene-1-carboxylic acid 
• 21472-50-4 2-hydroxy-2-phenyl-cyclohexanecarboxylic acid 
• 145450-39-1 2-phenyl-2-cyclohexene-1-carbonyl chloride 
• 24259-15-2 8-aza-8-methylbicyclo [3.2.1]oct-3-yl 2-phenylcyclohex-2-enecarboxylate 
• 1028312-90-4 1-(1,4-Dioxa-spiro[4.5]dec-6-ylmethyl)-4-phenyl-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Samarium diiodide mediated cascade radical cyclisations - Synthesis of the eudesmane tricyclic framework

Radical cascade cyclisation of methylenecyclopropyl cyclohexanone adducts, using samarium diiodide to generate an initial ketyl radical, provide a short route to tricyclic ethers, and the stereochemical outcome can be influenced by the solvent used for the reaction. (C) 2000 Elsevier Science Ltd.

Multicomponent reactions involving tricyclooxonium ylide intermediate: Diastereoselective synthesis of mono- and bisalkoxyoctahydro-1,4-benzodioxocin- 6(5H)-one frameworks

A highly diastereoselective tandem ring-enlargement and aldol condensation process involving multicomponent reactions of ethereal tricyclooxonium ylide intermediate with alcohols, mono- or dialdehydes in the presence of titanium(iv) isopropoxide is descri

Five Roads That Converge at the Cyclic Peroxy-Criegee Intermediates: BF3-Catalyzed Synthesis of β-Hydroperoxy-β-peroxylactones

We have discovered synthetic access to β-hydroperoxy-β-peroxylactones via BF3-catalyzed cyclizations of a variety of acyclic precursors, β-ketoesters and their silyl enol ethers, alkyl enol ethers, enol acetates, and cyclic acetals, with H2O2. Strikingly, independent of the choice of starting material, these reactions converge at the same β-hydroperoxy-β-peroxylactone products, i.e., the peroxy analogues of the previously elusive cyclic Criegee intermediate of the Baeyer-Villiger reaction. Computed thermodynamic parameters for the formation of the β-hydroperoxy-β-peroxylactones from silyl enol ethers, enol acetates, and cyclic acetals confirm that the β-peroxylactones indeed correspond to a deep energy minimum that connects a variety of the interconverting oxygen-rich species at this combined potential energy surface. The target β-hydroperoxy-β-peroxylactones were synthesized from β-ketoesters, and their silyl enol ethers, alkyl enol ethers, enol acetates, and cyclic acetals were obtained in 30-96% yields. These reactions proceed under mild conditions and open synthetic access to a broad selection of β-hydroperoxy-β-peroxylactones that are formed selectively even in those cases when alternative oxidation pathways can be expected. These β-peroxylactones are stable and can be useful for further synthetic transformations.

A mild, room-temperature protection of ketones and aldehydes as 1,3-dioxolanes under basic conditions

Protection of ketones or aldehydes as 1,3-dioxolane derivatives proceeds within minutes at room temperature in the presence of N- hydroxybenzenesulfonamide, its O-benzyl derivative, or the tosyl analogue, in the absence of strong protonic acids, and in the presence of base (Et). Acid-sensitive groups such as O-THP, O-TBS, or N-Boc are unaffected. Copyright

Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds

A process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds.

PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS

The present invention relates to a process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds.

CALCILYTIC COMPOUNDS

Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives

The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphati

Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones

Design, new synthesis, structure-activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are described.

Design, Pharmacokinetic, and Pharmacodynamic Evaluation of a New Class of Soft Anticholinergics

Purpose. To design and evaluate a new class of soft anticholinergics with subtype selectivity. Methods. A new class of soft anticholinergics was designed based on the "inactive metabolite" approach. Four compounds were synthesized. The potency and soft na