N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

Base Information

Chemical Name:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea
CAS No.:1311298-77-7
Molecular Formula:C₃₇H₃₇N₃O₄S
Molecular Weight:619.784
Hs Code.:

Synonyms:N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

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Chemical Property of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

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Technology Process of N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

There total 11 articles about N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1311298-75-5
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-tert-butyldimethylsilyloxymethylpyridine-2-yl)methyl]thiourea

: 1311298-77-7
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.05.046

Reference yield:

: 1311298-52-8
2-azidomethyl-6-tertbutyldimethylsilyloxymethylpyridine

: 1311298-77-7
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 5 h / 20 °C

2: chloroform-d1 / 5 h / Inert atmosphere; Reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform-d1;

Reference yield:

: 1195-59-1
2.6-bis(hydroxymethyl)pyridine

: 1311298-77-7
N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 12 h

2.1: carbon tetrabromide; triethylamine; sodium azide; triphenylphosphine / N,N-dimethyl-formamide / 25 h / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 5 h / 20 °C

4.1: chloroform-d1 / 5 h / Inert atmosphere; Reflux

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform-d1; N,N-dimethyl-formamide;