4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

Base Information

Chemical Name:4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester
CAS No.:1028268-07-6
Molecular Formula:C₃₇H₃₃N₃O₉
Molecular Weight:663.684
Hs Code.:

4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

Synonyms:4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

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Chemical Property of 4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

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Technology Process of 4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

There total 8 articles about 4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1026686-21-4
Carbonic acid benzyl ester 2,6-dimethoxy-4-((3aR,4R,10R)-4-methoxy-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl)-phenyl ester

: 619-45-4
4-methoxycarbonyl aniline

: 1028268-07-6
4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

Guidance literature:: With 4 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jm9508806

Reference yield:

: 66460-63-7
4-Hydroxy-3,5-dimethoxy-benzaldehyd-dimethylacetal

: 1028268-07-6
4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / p-TsOH / CH₂Cl₂; methanol / 4 h

2: 71 percent / TEA / CH₂Cl₂

3: 55 percent / 4A molecular sieves, BF₃*Et₂O / CH₂Cl₂ / 4 h / Ambient temperature

With 4 A molecular sieve; TEA; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jm9508806

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1028268-07-6
4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / TEA / CH₂Cl₂

2: 55 percent / 4A molecular sieves, BF₃*Et₂O / CH₂Cl₂ / 4 h / Ambient temperature

With 4 A molecular sieve; TEA; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/jm9508806