66460-63-7

Upstream product

• 90875-24-4 5-Bromovanilline dimethyl acetal 
• 124-41-4 sodium methylate 
• 134-96-3 syringic aldehyde 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 176915-14-3 (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[3,5-dimethoxy-4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one 
• 176915-13-2 (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[3-methoxy-4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one 
• 176915-12-1 (5R,11R,11aS)-4,5,11,11a-tetrahydro-5-[3,5-dimethoxy-4-(carbobenzoxyoxy)phenyl]-11-[4-(carbobenzoxyoxy)anilino]-1H,6H-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one 
• 176915-16-5 Carbonic acid benzyl ester 2,6-dimethoxy-4-[(3aS,4R,10R)-1-oxo-4-(3,4,5-trimethoxy-phenylamino)-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl]-phenyl ester 
• 1028268-07-6 4-[(3aS,4R,10R)-10-(4-Benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-4-ylamino]-benzoic acid methyl ester 
• 176915-15-4 Carbonic acid benzyl ester 2,6-dimethoxy-4-((3aS,4R,10R)-1-oxo-4-phenylamino-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl)-phenyl ester 
• 176915-23-4 Carbonic acid 2,6-dimethoxy-4-[(3aS,4R,10R)-4-(4-nitro-phenylamino)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl]-phenyl ester methyl ester 
• 176915-24-5 Carbonic acid 4-[(3aS,4R,10R)-4-(4-cyano-phenylamino)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl]-2,6-dimethoxy-phenyl ester methyl ester 
• 189884-89-7 Carbonic acid 4-[(3aS,4R,10R)-4-(4-fluoro-phenylamino)-1-oxo-3a,4,9,10-tetrahydro-3H-2-oxa-9,10a-diaza-cyclopenta[b]fluoren-10-yl]-2,6-dimethoxy-phenyl ester methyl ester 

Relevant academic research and scientific papers

Total syntheses of (+)-polygalolide A and (+)-polygalolide B: Elucidation of the absolute stereochemistry and biogenetic implications

The total syntheses of (+)-polygalolide A and (+)-polygalolide B have been completed by using a carbonyl ylide cycloaddition strategy. Three of the four stereocenters, including two consecutive tetrasubstituted carbon atoms at C2 and C8, were incorporated

Total synthesis and absolute stereochemistry of polygalolides A and B

(Chemical Equation Presented) Carbonyl ylides to the fore: the first total synthesis of polygalolides A (1) and B (2) has been achieved by exploiting a tandem carbonyl ylide formation/1,3-dipolar cycloaddition to construct the unprecedented 5,10-dioxatric

Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues

Eighteen analogues of the nonintercalative DNA topoisomerase II (topo II)-active epipodophyllotoxin-ellipticine hybrid, azatoxin, were synthesized and evaluated for their ability to induce topo II-mediated DNA strand breaks in vitro. In general, the SAR p

Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain

A series of novel C11-substituted derivatives of azaelliptitoxin (azatoxin) have been synthesized and tested for their inhibitory activity against human DNA topoisomerase II. Incorporation of a C11 polyamine or amine resulted in an i

Esters are effective co-catalysts in copper-catalyzed methanolysis of aryl bromides

Rate of copper(I)-catalyzed substitution of aryl bromides into methyl-aryl ethers by methoxide ion is greatly enhanced in presence of esters. Soluble copper(I) complexes 2, arising from tetrahedral adducts 1 of methoxide onto esters, are likely responsible for this improvement.