3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

Base Information

Chemical Name:3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid
CAS No.:117023-79-7
Molecular Formula:C₃₀H₃₃F₂NO₄
Molecular Weight:509.593
Hs Code.:

Synonyms:3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

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Chemical Property of 3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

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Technology Process of 3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

There total 6 articles about 3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 117023-77-5
3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid methyl ester

: 117023-79-7
3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 117023-79-7
3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / acetone / 24 h / Heating

2: 46 percent / Na₂CO₃, KI / dimethylformamide / Heating

3: 78 percent / KOH / H₂O; aq. ethanol / Heating

With potassium hydroxide; sodium carbonate; potassium carbonate; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-79-7
3-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 46 percent / Na₂CO₃, KI / dimethylformamide / Heating

4: 78 percent / KOH / H₂O; aq. ethanol / Heating

With potassium hydroxide; hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022