4-DIFLUOROMETHOXY-BIPHENYL

Base Information

• Chemical Name: 4-DIFLUOROMETHOXY-BIPHENYL
• CAS No.: 175838-98-9
• Molecular Formula: C₁₃H₁₀F₂O
• Molecular Weight: 220.219
• Hs Code.: 2909309090
• Mol file: 175838-98-9.mol

Synonyms:4-DIFLUOROMETHOXY-BIPHENYL

Chemical Property of 4-DIFLUOROMETHOXY-BIPHENYL

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 296.694°C at 760 mmHg
• Flash Point: 140.849°C
• PSA: 9.23000
• Density: 1.159g/cm³
• LogP: 3.95500

Purity/Quality:

98.5% ^*data from raw suppliers

4-Difluoromethoxybiphenyl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-DIFLUOROMETHOXY-BIPHENYL

There total 28 articles about 4-DIFLUOROMETHOXY-BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-Phenylphenol (92-69-3) + 1-(chlorodifluoromethylsulfonyl)-4-fluorobenzene (1321028-49-2) → 4-(difluoromethoxy)-1,1′-biphenyl (175838-98-9)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at -78 - 80 ℃; for 4h;

DOI:10.1016/j.jfluchem.2011.05.009

Reference yield: 93.0%

4-Phenylphenol (92-69-3) → 4-(difluoromethoxy)-1,1′-biphenyl (175838-98-9)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at -78 - 80 ℃; for 4h;

DOI:10.1016/j.jfluchem.2011.05.009

Reference yield: 87.0%

(chlorodifluoromethylsulfonyl)benzene (930836-30-9) + 4-Phenylphenol (92-69-3) → 4-(difluoromethoxy)-1,1′-biphenyl (175838-98-9)

Guidance literature:

With potassium hydroxide; In acetonitrile; at 50 ℃;

DOI:10.1039/b713156a

upstream raw materials:

4-Phenylphenol

2-chloro-2,2-difluoroacetophenone

(chlorodifluoromethylsulfonyl)benzene

1-(chlorodifluoromethylsulfonyl)-4-methylbenzene

Refernces

• 1、 Liu, Guo-Kai,Qin, Wen-Bing,Li, Xin,Lin, Li-Ting,Wong, Henry N. C.. "Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study". supporting information. p. 15948 - 15957. Retrieved 2019/11/16.
• 2、 Lin, Xiaoxi,Hou, Chuanqi,Li, Haohong,Weng, Zhiqiang. "Decarboxylative Trifluoromethylating Reagent [Cu(O2CCF3)(phen)] and Difluorocarbene Precursor [Cu(phen)2][O2CCF2Cl]". supporting information. p. 2075 - 2084. Retrieved 2016/02/12.