ChlorodifluoroMethyl phenyl sulfone

Base Information

• Chemical Name: ChlorodifluoroMethyl phenyl sulfone
• CAS No.: 930836-30-9
• Molecular Formula: C7H5ClF2O2S
• Molecular Weight: 226.631
• Hs Code.: 29309090
• Mol file: 930836-30-9.mol

Synonyms:ChlorodifluoroMethyl phenyl sulfone;((Chlorodifluoromethyl)sulfonyl)benzene

Chemical Property of ChlorodifluoroMethyl phenyl sulfone

Chemical Property:

• Boiling Point: 276.6±40.0 °C(Predicted)
• PSA: 42.52000
• Density: 1.476±0.06 g/cm3(Predicted)
• LogP: 3.33020

Purity/Quality:

98% ^*data from raw suppliers

[Chloro(difluoro)methyl]sulfonylbenzene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ChlorodifluoroMethyl phenyl sulfone

There total 4 articles about ChlorodifluoroMethyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

difluoromethyl phenyl sulfone (1535-65-5) → (chlorodifluoromethylsulfonyl)benzene (930836-30-9)

Guidance literature:

With sodium hypochlorite solution; In water; at 75 ℃; for 4h;

DOI:10.1016/j.tetlet.2012.09.121

Reference yield: 60.0%

[difluoro(phenylsulfonyl)methyl](trimethyl)silane (536975-50-5) → (chlorodifluoromethylsulfonyl)benzene (930836-30-9)

Guidance literature:

With cesium fluoride; copper dichloride; In N,N-dimethyl-formamide; at -30 - 0 ℃; for 20h; Inert atmosphere;

DOI:10.1055/s-0030-1259676

Reference yield:

(trichloromethylthio)benzene (701-65-5) → (chlorodifluoromethylsulfonyl)benzene (930836-30-9) + (trifluoromethylsulfonyl)benzene (426-58-4)

Guidance literature:

(trichloromethylthio)benzene; With pyridine hydrogenfluoride; at 20 ℃; for 4h;

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 10h; Further stages. Title compound not separated from byproducts.;

DOI:10.1039/b713156a

upstream raw materials:

(trichloromethylthio)benzene

difluoromethyl phenyl sulfone

[(bromodifluoromethyl)sulfonyl]benzene

[difluoro(phenylsulfonyl)methyl](trimethyl)silane

Downstream raw materials:

2-(3-chloro-5-(difluoromethoxy)phenyl)-1,3-dioxolane

1-(difluoromethyl)-2-phenyl-1H-imidazole

1-difluoromethoxy-4-nitrobenzene

2-(difluoromethyl)-1-phenylpyrazolidin-3-one

Refernces

• 1、 Zhu, Jieming,Wang, Fei,Huang, Weizhou,Zhao, Yanchuan,Ye, Wenchao,Hu, Jinbo. "Copper-mediated fluoroalkylation reactions with [(phenylsulfonyl)- difluoromethyl]trimethylsilane: Synthesis of PhSO2CF 2-containing allenes and alkynes". . p. 899 - 902. Retrieved 2011/06/19.