3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

Base Information

Chemical Name:3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester
CAS No.:133191-93-2
Molecular Formula:C₂₀H₂₁ClO₁₁
Molecular Weight:472.833
Hs Code.:

Synonyms:3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

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Chemical Property of 3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

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Technology Process of 3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

There total 4 articles about 3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 67919-37-3
1,2,3,4--tetra--O--acetyl-β-D--glucuronic acid

: 937-14-4
3-chloro-benzenecarboperoxoic acid

: 133191-93-2
3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃; for 0.25h;
DOI:10.1021/jo00002a009

Reference yield:

: 6556-12-3,489-91-8,528-16-5,552-12-5,577-46-8,643-33-4,2240-07-5,6294-16-2,10133-02-5,18402-78-3,18968-14-4,21179-08-8,23018-83-9,33599-45-0,33599-46-1,46171-67-9,46171-69-1,46172-26-3,70021-34-0,71031-08-8,104195-06-4,106499-29-0,124817-72-7
D-glucuronic acid

: 133191-93-2
3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; H₂O / 10 h

2: pyridine / 10 h

3: 0.6 g / H₂ / 10percent Pd/C / tetrahydrofuran

4: 39 percent / DCC / ethyl acetate / 0.25 h / 0 °C

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jo00002a009

Reference yield:

: (2S,3S,4S,5R)-3,4,5,6-Tetrahydroxy-tetrahydro-pyran-2-carboxylic acid benzhydryl ester

: 133191-93-2
3-Chloro-benzoic acid (2R,3S,4R,5R)-3,4,5,6-tetraacetoxy-tetrahydro-pyran-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 10 h

2: 0.6 g / H₂ / 10percent Pd/C / tetrahydrofuran

3: 39 percent / DCC / ethyl acetate / 0.25 h / 0 °C

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00002a009