N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid

Base Information

• Chemical Name: N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid
• CAS No.: 153052-72-3
• Molecular Formula: C₃₁H₄₈N₂O₉
• Molecular Weight: 592.73

Synonyms:N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid

Chemical Property of N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid

There total 7 articles about N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactate (153153-72-1) → N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid (153052-72-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 2280 Torr;

DOI:10.7164/antibiotics.47.1322

Reference yield:

(2R)-1-(benzyloxy)-1-oxopropan-2-yl (2S)-4-methyl-2-(methylamino)pentanoate (153052-69-8) → N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid (153052-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / (i-Pr)2NEt; N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 0 °C

2: H₂ / Pd/C / ethyl acetate

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1021/jo001749v

Reference yield:

Boc-L-MeLeu-D-PhLac-OH (153052-71-2) → N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactic acid (153052-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / (i-Pr)2NEt; N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 0 °C

2: H₂ / Pd/C / ethyl acetate

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1021/jo001749v

upstream raw materials:

benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactate

benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactate

(2R)-1-(benzyloxy)-1-oxopropan-2-yl (2S)-4-methyl-2-(methylamino)pentanoate

Boc-L-MeLeu-D-PhLac-OH

Downstream raw materials:

benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactate

C₆₂H₉₀N₆O₁₅

(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (R)-1-{[(S)-1-((R)-1-{[(S)-1-((R)-1-benzyloxycarbonyl-2-phenyl-ethoxycarbonyl)-3-methyl-butyl]-methyl-carbamoyl}-ethoxycarbonyl)-3-methyl-butyl]-methyl-carbamoyl}-2-phenyl-ethyl ester

C₅₀H₇₆N₆O₁₃

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