4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide
• CAS No.: 865603-96-9
• Molecular Formula: C₁₆H₁₅I₂N₃O₃S
• Molecular Weight: 583.188

Synonyms:4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide

Chemical Property of 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide

Chemical Property:

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Technology Process of 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide

There total 6 articles about 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(3,4-diiodo-1H-indazol-7-yl)-4-methoxy-N-methyl-benzenesulfonamide (865603-95-8) + methyl iodide (74-88-4) → 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide (865603-96-9)

Guidance literature:

With potassium hydroxide; In acetone; at 0 ℃;

DOI:10.1016/j.tetlet.2005.06.080

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide (865603-96-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / methanol

1.2: 95 percent / pyridine / methanol

2.1: 98 percent / I₂ / pyridine / 3 h / 20 °C

3.1: 86 percent / KOH / acetone / 0 °C

4.1: 98 percent / I₂; KOH / dimethylformamide / 20 °C

5.1: 90 percent / KOH / acetone / 0 °C

With potassium hydroxide; hydrogen; iodine; palladium on activated charcoal; In pyridine; methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetlet.2005.06.080

Reference yield:

7-Nitroindazole (2942-42-9) → 4-methoxy-N-methyl-N-(3,4-diiodo-1-methyl-7-indazolyl)benzenesulfonamide (865603-96-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / methanol

1.2: 95 percent / pyridine / methanol

2.1: 98 percent / I₂ / pyridine / 3 h / 20 °C

3.1: 86 percent / KOH / acetone / 0 °C

4.1: 98 percent / I₂; KOH / dimethylformamide / 20 °C

5.1: 90 percent / KOH / acetone / 0 °C

With potassium hydroxide; hydrogen; iodine; palladium on activated charcoal; In pyridine; methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.tetlet.2005.06.080

upstream raw materials:

N-(3,4-diiodo-1H-indazol-7-yl)-4-methoxy-N-methyl-benzenesulfonamide

methyl iodide

4-methoxy-N-(7-indazolyl)benzenesulfonamide

4-methoxy-N-(4-iodo-7-indazolyl)benzenesulfonamide

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