3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

Base Information

Chemical Name:3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate
CAS No.:929258-75-3
Molecular Formula:C₂₃H₂₃NO₅
Molecular Weight:393.439
Hs Code.:

Synonyms:3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

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Chemical Property of 3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

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Technology Process of 3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

There total 4 articles about 3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 929258-60-6
ethyl N-benzyl-11-oxo-1,3,4,6-tetrahydro-1,5-methano-3-benzazocine-5(2H)-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 929258-75-3
3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

Guidance literature:: at 80 ℃; for 168h;
DOI:10.1002/ejoc.200600688

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 929258-75-3
3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / K₂CO₃ / tetrahydrofuran / 6 h / Heating

2: 65 percent / K₃PO₄; tBu₃P; Pd(dba)2 / toluene / 12 h / 110 °C

3: 70 percent / 168 h / 80 °C

With potassium phosphate; tri-tert-butyl phosphine; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; 2: intramolecular Buchwald-Hartwig cyclization;
DOI:10.1002/ejoc.200600688

Reference yield:

: 929258-59-3
ethyl N-benzyl-3-(2-bromobenzyl)-4-oxopiperidine-3-carboxylate

: 929258-75-3
3-benzyl 5-ethyl 11-oxo-1,6-dihydro-1,5-methano-3-benzazocine-3,5(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / K₃PO₄; tBu₃P; Pd(dba)2 / toluene / 12 h / 110 °C

2: 70 percent / 168 h / 80 °C

With potassium phosphate; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; 1: intramolecular Buchwald-Hartwig cyclization;
DOI:10.1002/ejoc.200600688