Thiazolo[4,5-b]pyridine, 2-methyl- (9CI)

Base Information

• Chemical Name: Thiazolo[4,5-b]pyridine, 2-methyl- (9CI)
• CAS No.: 175659-41-3
• Molecular Formula: C₇H₆N₂S
• Molecular Weight: 150.204
• Mol file: 175659-41-3.mol

Synonyms:Thiazolo[4,5-b]pyridine, 2-methyl- (9CI)

Chemical Property of Thiazolo[4,5-b]pyridine, 2-methyl- (9CI)

Chemical Property:

• Boiling Point: 252.2±13.0 °C(Predicted)
• PKA: 0.74±0.50(Predicted)
• PSA: 54.02000
• Density: 1.297±0.06 g/cm3(Predicted)
• LogP: 1.99970

Purity/Quality:

99%,98%, ^*data from raw suppliers

2-methyl-Thiazolo[4,5-b]pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiazolo[4,5-b]pyridine, 2-methyl- (9CI)

There total 6 articles about Thiazolo[4,5-b]pyridine, 2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetyl chloride (75-36-5) + 2-amino-3-(diisopropyldithiocarbamato)pyridine → 2-methylthiazolo[4,5-b]pyridine (175659-41-3)

Guidance literature:

acetyl chloride; 2-amino-3-(diisopropyldithiocarbamato)pyridine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In water; at 100 ℃; for 5h; Inert atmosphere;

With sodium hydroxide; In water; at 0 ℃; pH=7-8;

Reference yield:

6-Chloro-2-methyl-thiazolo[4,5-b]pyridine → 2-methylthiazolo[4,5-b]pyridine (175659-41-3)

Guidance literature:

With hydrogen; palladium on activated charcoal;

Reference yield:

3,5-dichloropyridin-2-amine (4214-74-8) → 2-methylthiazolo[4,5-b]pyridine (175659-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiH

2: H₂ / Pd/C

With hydrogen; lithium hydride; palladium on activated charcoal;

upstream raw materials:

N-pyridyl-2'-thioacetamide

3,5-dichloropyridin-2-amine

N-(2-pyridyl)acetamide

acetyl chloride

Downstream raw materials:

(thiazolo[4,5-b]pyridin-2-yl)carboxylic acid

Refernces

• 1、 Chimichi, Stefano,Tedeschi, Piero,Calvietti, Stefano,Ponticelli, Fabio. "Carbon-13 NMR studies on azolopyridines: 4 - The thiazolopyridine systems". . p. 601 - 605. Retrieved 2007/10/03.