4214-74-8Relevant articles and documents
tert-BUTYLDIAZENE OXIDE AS A LEAVING GROUP
Filatov, I. E.,Kulikov, Yu. V.,Rusinov, G. L.,Pashkevich, K. I.
, p. 834 (1990)
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Selectfluor-promoted regioselective chlorination/bromination of 2-aminopyridines and 2-aminodiazines using LiCl/LiBr
Hu, Jiao,Zhou, Gang,Tian, Yawei,Zhao, Xiaoming
supporting information, p. 6342 - 6345 (2019/07/10)
Using LiCl as a chlorine source, the chlorination of 2-aminopyridines or 2-aminodiazines in the presence of Selectfluor and DMF is established under mild conditions. This method gives chlorinated pyridines or diazines in good to high yields with high regioselectivities. Also, this method is extended to the bromination of 2-aminopyridines or 2-aminodiazines by using LiBr. The regioselectivity of the chlorination reaction is strongly dependent upon the substituent pattern in either the 2-aminopyridines or 2-aminodiazines. The synthesis of Buparlisib from chlorinated pyridines was explored. A study of the mechanism revealed that this chlorination occurs via either a pyridine or diazine radical process.
CFBSA: a novel and practical chlorinating reagent
Lu, Zehai,Li, Qingwei,Tang, Minghua,Jiang, Panpan,Zheng, Hao,Yang, Xianjin
supporting information, p. 14852 - 14855 (2015/10/06)
A structurally simple, highly reactive chlorinating reagent, N-chloro-N-fluorobenzenesulfonylamine (CFBSA), was conveniently prepared from inexpensive Chloramine B in high yield. A wide range of substrates were chlorinated with it to obtain products in good to high yields and appropriate selectivity.