Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-

Base Information

Chemical Name:Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-
CAS No.:332135-64-5
Molecular Formula:C₁₆H₁₂BrNO₃S
Molecular Weight:378.246
Hs Code.:
DSSTox Substance ID:DTXSID501217176
Nikkaji Number:J1.674.112D

Synonyms:332135-64-5;Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-;DTXSID501217176;2-Bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]ethanone

Suppliers and Price of Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:376.97213
Heavy Atom Count:22
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=CC=CC=C32)C(=O)CBr

Technology Process of Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]-

There total 3 articles about Ethanone, 2-bromo-1-[1-(phenylsulfonyl)-1H-indol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 99532-45-3
3-acetyl-1-benzenesulfonylindole

: 332135-64-5
1-[1-(benzenesulfonyl)-1H-indol-3-yl]-2-bromoethan-1-one

Guidance literature:: With copper(ll) bromide; In ethyl acetate; for 0.833333h; Heating;
DOI:10.3987/com-01-s(k)30

Reference yield: 55.0%

: 99532-45-3
3-acetyl-1-benzenesulfonylindole

: 916818-21-8
3-(1-benzenesulfonyl-1H-indol-3-yl)-2,2-dibromoethanone

: 332135-64-5
1-[1-(benzenesulfonyl)-1H-indol-3-yl]-2-bromoethan-1-one

Guidance literature:: With pyridinium hydrobromide perbromide; In chloroform; for 0.5h; Heating;
DOI:10.1016/j.tet.2006.09.003

Reference yield:

: 703-80-0
3-acetylindole

: 98-09-9
benzenesulfonyl chloride

: 332135-64-5
1-[1-(benzenesulfonyl)-1H-indol-3-yl]-2-bromoethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 20 °C

2.1: bromine / ethanol / 2 h / Inert atmosphere; Reflux

With bromine; sodium hydride; In tetrahydrofuran; ethanol; mineral oil;
DOI:10.3390/md14120226