(S)-2-pyrrolidinemethanol

Base Information

• Chemical Name: (S)-2-pyrrolidinemethanol
• CAS No.: 1616352-91-0
• Molecular Formula: C₁₈H₂₆BNO₄
• Molecular Weight: 331.22
• Mol file: 1616352-91-0.mol

Synonyms:(S)-2-pyrrolidinemethanol

Chemical Property of (S)-2-pyrrolidinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-2-pyrrolidinemethanol

There total 2 articles about (S)-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-2-pyrrolidinemethanol (1568178-14-2) + bis(pinacol)diborane (73183-34-3) → (S)-2-pyrrolidinemethanol (1616352-91-0)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In dimethyl sulfoxide; at 70 ℃; for 16h;

DOI:10.1039/c4cc02559h

Reference yield:

4-iodobenzoic acid chloride (1711-02-0) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → (S)-2-pyrrolidinemethanol (1616352-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate / dimethyl sulfoxide / 16 h / 70 °C

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/c4cc02559h

Reference yield: 68.0%

32,35,52,55,72,75,92,95-octamethoxy-1,3,5,7,9(1,4)-pentabenzenacyclodecaphane-12,15-diyl bis(trifluoromethanesulfonate) (1402919-93-0) + (S)-2-pyrrolidinemethanol (1616352-91-0) → C67H72N2O12 (1616352-92-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In tetrahydrofuran; water; at 80 ℃; for 24h;

DOI:10.1039/c4cc02559h

upstream raw materials:

4-iodobenzoic acid chloride

(S)-1-Pyrrolidin-2-yl-methanol

(S)-2-pyrrolidinemethanol

bis(pinacol)diborane

Downstream raw materials:

C₆₇H₇₂N₂O₁₂