1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

Base Information

Chemical Name:1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate
CAS No.:1202179-14-3
Molecular Formula:C₂₇H₃₄F₂N₄O₃
Molecular Weight:500.589
Hs Code.:

Synonyms:1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

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Chemical Property of 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

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Technology Process of 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

There total 5 articles about 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2306252-57-1
2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester

: 1137951-00-8
(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

: 1202179-14-3
1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 15h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1202179-14-3
1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dmap / chloroform / 18 h / 0 - 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; dmap; 20% palladium hydroxide on carbon; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 885275-27-4
2-benzyl 2,7-diaza-spiro-[4.4]nonane

: 1202179-14-3
1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dmap / chloroform / 18 h / 0 - 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; dmap; 20% palladium hydroxide on carbon; In methanol; chloroform; N,N-dimethyl-formamide;