(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

Base Information

Chemical Name:(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime
CAS No.:1202179-20-1
Molecular Formula:C₂₂H₂₆F₂N₄O
Molecular Weight:400.471
Hs Code.:

Synonyms:(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

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Chemical Property of (E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

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Technology Process of (E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

There total 6 articles about (E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202179-14-3
1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

: 1202179-20-1
(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

Guidance literature:: 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate; With trifluoroacetic acid; In chloroform; at 0 - 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In chloroform; water;

Reference yield:

: 885275-27-4
2-benzyl 2,7-diaza-spiro-[4.4]nonane

: 1202179-20-1
(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dmap / chloroform / 18 h / 0 - 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

4: trifluoroacetic acid / chloroform / 0.5 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; dmap; 20% palladium hydroxide on carbon; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1177266-41-9
tert-butyl 7-benzyl-2,7-diazaspiro[4.4]nonane-2-carboxylate

: 1202179-20-1
(E)-[5-(2,7-diazaspiro[4.4]non-2-ylmethyl)-2-pyridinyl](3,4-difluorophenyl)methanone O-ethyloxime

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 20% palladium hydroxide on carbon / methanol / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 15 h / 80 °C

3: trifluoroacetic acid / chloroform / 0.5 h / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; 20% palladium hydroxide on carbon; In methanol; chloroform; N,N-dimethyl-formamide;