(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

Base Information

• Chemical Name: (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate
• CAS No.: 1137951-00-8
• Molecular Formula: C₁₆H₁₆F₂N₂O₄S
• Molecular Weight: 370.377

Synonyms:(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

Chemical Property of (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

Chemical Property:

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Technology Process of (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate

There total 1 articles about (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime (1017599-32-4) + methanesulfonyl chloride (124-63-0) → (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate (1137951-00-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2009.07.132

Reference yield:

2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester (2306252-57-1) + (6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate (1137951-00-8) → 1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate (1202179-14-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 15h;

Reference yield:

(6-{(E)-(3,4-Difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl methanesulfonate (1137951-00-8) + 2-(6-Fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]nonane (1202179-07-4) → (E)-(3,4-difluorophenyl)(5-{[7-(6-fluoro-3-pyridinyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime (1202177-48-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 0.0833333h; Microwaves;

upstream raw materials:

(E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime

methanesulfonyl chloride

Downstream raw materials:

1'-({6-[(E)-(3,4-difluorophenyl)(ethoxyimino)methyl]pyridin-3-yl}methyl)-5-methyl-3,5-dihydro-6H-spiro[furo[3,4-c]pyridine-1,4'-piperidin]-6-one

C₂₆H₂₅F₃N₄O₂

C₂₇H₂₈F₂N₄O₃

1,1-Dimethylethyl 7-[(6-{[E)-(3,4-difluorophenyl)[(ethyloxy)imino]methyl}-3-pyridinyl)methyl]-2,7-diazaspiro[4.4]nonane-2-carboxylate

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