5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

Base Information

Chemical Name:5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole
CAS No.:1148104-71-5
Molecular Formula:C₁₇H₁₇F₂N₃OS
Molecular Weight:349.404
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

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Technology Process of 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

There total 15 articles about 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: tert-butyl 4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidine-1-carboxylate

: 1148104-71-5
5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

Guidance literature:: With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 1173693-37-2
2-bromo-1-(4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl)ethanone

: 1148104-71-5
5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

Guidance literature:: tert-butyl 4-carbamothioylpiperidine-1-carboxylate; 2-bromo-1-(4,5-dihydro-5-(2,6-difluorophenyl)-3-isoxazolyl)ethanone; In acetone; at 20 - 45 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 437-81-0
2,6-difluorobenzaldehyde

: 1148104-71-5
5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / 10 - 20 °C

3: bromine / dichloromethane / 20 °C

4: methanol / 2 h / 20 - 50 °C / Inert atmosphere

5: hydrogenchloride / water; dichloromethane

With hydrogenchloride; bromine; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 1: |Wittig Rearrangement;