methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate
CAS No.:1225441-57-5
Molecular Formula:C₄₀H₃₉NO₁₁
Molecular Weight:709.75
Hs Code.:

methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

Synonyms:methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

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Chemical Property of methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

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Technology Process of methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

There total 15 articles about methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1225441-53-1
4-methoxy-3-(methoxymethoxy)phenylboronic acid

: 1225441-56-4
methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-4-oxo-1-(trifluoromethanesulfonyloxy)-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

: 1225441-57-5
methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; for 8h; Reflux;
DOI:10.3987/COM-09-S(S)100

Reference yield: 94.0%

: 1225441-56-4
methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-4-oxo-1-(trifluoromethanesulfonyloxy)-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

: 1352336-46-9
2-[4-methoxy-3-(methoxymethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1225441-57-5
methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; for 3h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2011.10.030

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 1225441-57-5
methyl 7-benzyloxy-3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-8-methoxy-1-[4-methoxy-3-(methoxymethoxy)phenyl]-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 9 h / Inert atmosphere; Reflux

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

2.3: pH 3

3.1: dichloromethane / 26 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; sodium carbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetone; 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.10.030