(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

Base Information

Chemical Name:(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol
CAS No.:184719-76-4
Molecular Formula:C₃₉H₆₆O₄Si
Molecular Weight:627.036
Hs Code.:

(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

Synonyms:(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

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Chemical Property of (3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

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Technology Process of (3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

There total 7 articles about (3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 184719-65-1
(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-(2-hydroxy-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

: 184719-76-4
(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

Guidance literature:: With dmap; In dichloromethane; for 4h; Ambient temperature;

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 184719-76-4
(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / KOH / dimethylformamide / 8 h / 10 - 20 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 1 h / 50 °C

3: 85 percent / KOH / dimethylformamide / 3 h / -10 - 0 °C

4: aq. NaIO₄ / OsO₄ / diethyl ether / 4 h / Ambient temperature

5: 83 percent / NaBH₄ / diethyl ether; ethanol / 1 h / Ambient temperature

6: 95 percent / DMAP / CH₂Cl₂ / 4 h / Ambient temperature

With dmap; potassium hydroxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 100-39-0
benzyl bromide

: 184719-76-4
(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / KOH / dimethylformamide / 3 h / -10 - 0 °C

2: aq. NaIO₄ / OsO₄ / diethyl ether / 4 h / Ambient temperature

3: 83 percent / NaBH₄ / diethyl ether; ethanol / 1 h / Ambient temperature

4: 95 percent / DMAP / CH₂Cl₂ / 4 h / Ambient temperature

With dmap; potassium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;