N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide

Base Information

• Chemical Name: N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide
• CAS No.: 1351500-17-8
• Molecular Formula: C₂₁H₁₆FN₃O₃S
• Molecular Weight: 409.441
• Mol file: 1351500-17-8.mol

Synonyms:N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide

Chemical Property of N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide

There total 4 articles about N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanamine (1031602-06-8) + benzenesulfonyl chloride (98-09-9) → N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide (1351500-17-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2011.09.099

Reference yield:

(2RS)-N-(p-fluorophenyl)glycine (7292-73-1) → N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide (1351500-17-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.67 h / 0 °C

2.2: 0.83 h / 0 °C

2.3: 2 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 °C

With sodium hydrogencarbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.09.099

Reference yield:

tert-butyl (4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methylcarbamate (1351500-10-1) → N-((4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)benzenesulfonamide (1351500-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2011.09.099

upstream raw materials:

2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid

tert-butyl (4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methylcarbamate

(4-fluorophenyl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanamine

benzenesulfonyl chloride