N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

Base Information

Chemical Name:N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine
CAS No.:872728-72-8
Molecular Formula:C₂₅H₃₃NO₆S
Molecular Weight:475.606
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

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Chemical Property of N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

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Technology Process of N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

There total 4 articles about N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 872728-78-4
(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 872728-72-8
N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2005.09.046

Reference yield: 16.0%

: 27846-25-9
1-phenyl-2-(phenylsulfonyl)ethane

: 24424-99-5
di-tert-butyl dicarbonate

: 131319-74-9
(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine

: N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

: 872728-72-8
N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

: N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

Guidance literature:: 1-phenyl-2-(phenylsulfonyl)ethane; (R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 5h;

di-tert-butyl dicarbonate; With hydrogen; palladium dihydroxide; In ethyl acetate; at 20 ℃; for 24h; atmospheric pressure;
DOI:10.1016/j.tet.2005.09.046

Reference yield:

: 16212-06-9
phenyl styryl sulfone

: 872728-72-8
N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 18 percent / n-BuLi / tetrahydrofuran / 7 h / -78 - 0 °C

2: 80 percent / tetrahydrofuran / 15 h / 20 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.tet.2005.09.046