(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

Base Information

Chemical Name:(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine
CAS No.:872728-78-4
Molecular Formula:C₂₀H₂₅NO₄S
Molecular Weight:375.489
Hs Code.:

Synonyms:(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

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Chemical Property of (1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

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Technology Process of (1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

There total 1 articles about (1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 16212-06-9
phenyl styryl sulfone

: 131319-74-9
(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine

: 872728-78-4
(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

: 872728-77-3
(1S,2S)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

: [(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propyl]-[1-phenyl-meth-(E)-ylidene]-amine

: [(1S,2S)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propyl]-[1-phenyl-meth-(E)-ylidene]-amine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 7h;
DOI:10.1016/j.tet.2005.09.046

Reference yield: 80.0%

: 872728-78-4
(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 872728-72-8
N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenyl-2-(phenylsulfonyl)propylamine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2005.09.046

Reference yield:

: 872728-78-4
(1S,2R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-phenyl-propylamine

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / tetrahydrofuran / 15 h / 20 °C

2: 72 percent / Na-Hg / methanol / 1 h / 20 °C

3: 83 percent / CF₃COOH / methanol; H₂O / 7 h / 20 °C

4: 71 percent / NaIO₄ / RuCl₃ / acetonitrile; CCl₄; H₂O / 1 h / 20 °C

With sodium periodate; sodium amalgam; trifluoroacetic acid; ruthenium trichloride; In tetrahydrofuran; methanol; tetrachloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2005.09.046