N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide
CAS No.:1315585-24-0
Molecular Formula:C₂₈H₃₃N₉O₂S
Molecular Weight:559.695
Hs Code.:

Synonyms:N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

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Chemical Property of N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

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Technology Process of N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

There total 8 articles about N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 26371-07-3
1-piperidinepropionic acid

: 1334320-78-3
C₂₀H₂₀N₈OS

: 1315585-24-0
N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1160995-45-8
2,4-dichloro-6-nitropyrrolo[2,1-f][1,2,4]triazine

: 1315585-24-0
N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrogen / Raney nickel / tetrahydrofuran; methanol

4.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h / 20 °C

With dmap; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; Raney nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1204245-52-2
1-amino-4-nitro-1H-pyrrole-2-carboxamide

: 1315585-24-0
N-(4-((6-(3-(piperidin-1-yl)propanamido)-4-(5-methyl-1H-pyrazol-3-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 1,4-dioxane / 1 h / Reflux

2.1: triethylamine; trichlorophosphate / Inert atmosphere; Reflux

3.1: potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 2 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran; methanol

6.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; trichlorophosphate; Raney nickel; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;