4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate
CAS No.:471905-62-1
Molecular Formula:C₁₉H₁₄ClF₅O₅S₂
Molecular Weight:516.894
Hs Code.:

Synonyms:4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

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Chemical Property of 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

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Technology Process of 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

There total 7 articles about 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 471903-20-5
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 471905-62-1
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -75 - 20 ℃;
DOI:10.1021/jo070407n

Reference yield:

: 470716-52-0
2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene

: 471905-62-1
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H₂O; toluene / 45 °C

2: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C

3: xylene / 16 h / 130 °C

4: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C

5: 67 percent / lithium diisopropylamide / tetrahydrofuran / -75 - 20 °C

With hydrogenchloride; sodium tungstate; sulfuric acid; dihydrogen peroxide; acetic anhydride; lithium diisopropyl amide; Aliquat 336; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; xylene; 3: Diels-Alder reaction;
DOI:10.1021/jo070407n

Reference yield:

: 106-54-7
p-Chlorothiophenol

: 471905-62-1
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-en-1-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / sodium hydroxide / ethanol / cooling

2: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H₂O; toluene / 45 °C

3: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C

4: xylene / 16 h / 130 °C

5: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C

6: 67 percent / lithium diisopropylamide / tetrahydrofuran / -75 - 20 °C

With hydrogenchloride; sodium hydroxide; sodium tungstate; sulfuric acid; dihydrogen peroxide; acetic anhydride; lithium diisopropyl amide; Aliquat 336; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; xylene; 4: Diels-Alder reaction;
DOI:10.1021/jo070407n