Technology Process of 3-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-enyl]propanoic acid
There total 9 articles about 3-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohex-1-enyl]propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C
2: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C
3: xylene / 16 h / 130 °C
4: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C
5: 67 percent / lithium diisopropylamide / tetrahydrofuran / -75 - 20 °C
6: bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 1.5 h / 50 °C
7: 1.3 g / LiOH*H2O / tetrahydrofuran; H2O / 5 h / 65 °C
With
hydrogenchloride; lithium hydroxide; sodium tungstate; sulfuric acid; dihydrogen peroxide; acetic anhydride; lithium diisopropyl amide;
bis(triphenylphosphine)palladium(II)-chloride; Aliquat 336;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; xylene;
3: Diels-Alder reaction;
DOI:10.1021/jo070407n
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C
2: xylene / 16 h / 130 °C
3: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C
4: 67 percent / lithium diisopropylamide / tetrahydrofuran / -75 - 20 °C
5: bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 1.5 h / 50 °C
6: 1.3 g / LiOH*H2O / tetrahydrofuran; H2O / 5 h / 65 °C
With
hydrogenchloride; lithium hydroxide; acetic anhydride; lithium diisopropyl amide;
bis(triphenylphosphine)palladium(II)-chloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; xylene;
2: Diels-Alder reaction;
DOI:10.1021/jo070407n
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / sodium hydroxide / ethanol / cooling
2: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C
3: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C
4: xylene / 16 h / 130 °C
5: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C
6: 67 percent / lithium diisopropylamide / tetrahydrofuran / -75 - 20 °C
7: bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 1.5 h / 50 °C
8: 1.3 g / LiOH*H2O / tetrahydrofuran; H2O / 5 h / 65 °C
With
hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium tungstate; sulfuric acid; dihydrogen peroxide; acetic anhydride; lithium diisopropyl amide;
bis(triphenylphosphine)palladium(II)-chloride; Aliquat 336;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; xylene;
4: Diels-Alder reaction;
DOI:10.1021/jo070407n