(2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

Base Information

Chemical Name:(2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane
CAS No.:127001-02-9
Molecular Formula:C₁₂H₁₂ClN₃O
Molecular Weight:249.7
Hs Code.:

Synonyms:(2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

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Chemical Property of (2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

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Technology Process of (2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

There total 14 articles about (2R,3S)-2-(4-Chlorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126945-35-5,138989-97-6,150852-14-5
Methanesulfonic acid (1S,2S)-2-(4-chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

: 126917-50-8,127001-02-9,132563-78-1
1-[(2R,3S)-2-(4-Chloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 115 ℃; for 0.5h;
DOI:10.1248/cpb.38.2476

Reference yield:

: 49656-24-8
1-(4-chlorophenyl)-2-hydroxypropan-1-one

: 126917-50-8,127001-02-9,132563-78-1
1-[(2R,3S)-2-(4-Chloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h / Ambient temperature

2: 1) NaH / 1) DMSO, rt, 1 h, 2) DMSO, rt, 1 h

3: 84 percent / tert-BuOK / dimethylformamide / 1 h / 100 °C

4: p-toluenesulfonic acid / methanol / 1 h / Ambient temperature

5: 87 percent / pyridine / 2 h / Ambient temperature

6: NaN₃, NH₄Cl / dimethylformamide / 0.5 h / 115 °C

With pyridine; sodium azide; potassium tert-butylate; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; pyridinium p-toluenesulfonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476

Reference yield:

: 877-37-2
2-bromo-1-(4-chlorophenyl)-1-propanone

: 126917-50-8,127001-02-9,132563-78-1
1-[(2R,3S)-2-(4-Chloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 7 steps

1: LiOH / dimethylformamide; H₂O / 2 h / 0 °C

2: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h / Ambient temperature

3: 1) NaH / 1) DMSO, rt, 1 h, 2) DMSO, rt, 1 h

4: 84 percent / tert-BuOK / dimethylformamide / 1 h / 100 °C

5: p-toluenesulfonic acid / methanol / 1 h / Ambient temperature

6: 87 percent / pyridine / 2 h / Ambient temperature

7: NaN₃, NH₄Cl / dimethylformamide / 0.5 h / 115 °C

With pyridine; lithium hydroxide; sodium azide; potassium tert-butylate; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; pyridinium p-toluenesulfonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2476