(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

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Chemical Name:(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone
CAS No.:1442444-99-6
Molecular Formula:C₂₆H₂₈Cl₂N₄O
Molecular Weight:483.441
Hs Code.:

Synonyms:(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

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Chemical Property of (4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

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Technology Process of (4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

There total 7 articles about (4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1442445-25-1
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

: 1442444-99-6
(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442444-99-6
(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: hydrogenchloride; iron / water / 2 h / 90 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2 h / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: HATU; N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (S)-Mandelic acid; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1442445-21-7
(R)-5-bromo-N-(1-(2,4-dichlorophenyl)ethyl)-2-nitroaniline

: 1442444-99-6
(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; iron / water / 2 h / 90 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: HATU; N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; water;