(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

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Chemical Name:(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate
CAS No.:1442445-25-1
Molecular Formula:C₃₁H₃₆Cl₂N₄O₃
Molecular Weight:583.558
Hs Code.:

Synonyms:(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

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Technology Process of (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89981-75-9
1-(2',4'-dichlorophenyl)ethylamine

: 1442445-25-1
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: (S)-Mandelic acid / isopropyl alcohol; ethanol / 26 h / 30 - 60 °C / Resolution of racemate

1.2: 1 h / 20 °C / Resolution of racemate

2.1: potassium carbonate / dimethyl sulfoxide / 1 h / 120 °C

3.1: hydrogenchloride; iron / water / 2 h / 90 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2 h / 100 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: HATU; N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (S)-Mandelic acid; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1442445-24-0
(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazole

: 28697-17-8
N-BOC-D-pipecolic acid

: 1442445-25-1
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1442445-21-7
(R)-5-bromo-N-(1-(2,4-dichlorophenyl)ethyl)-2-nitroaniline

: 1442445-25-1
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-benzo[d]imidazol-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; iron / water / 2 h / 90 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 2 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: HATU; N-ethyl-N,N-diisopropylamine / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; water;