(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

Base Information

Chemical Name:(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide
CAS No.:1257638-06-4
Molecular Formula:C₃₂H₂₄Cl₂FIN₈O₃
Molecular Weight:785.403
Hs Code.:

(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

Synonyms:(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

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Chemical Property of (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

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Technology Process of (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

There total 16 articles about (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159735-91-7
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

: 1-amino-cyclopropanecarboxylic acid [1-(5-iodo-pyrimidin-2-yl)-cyclopropyl]-amide dihydrochloride

: 1257638-06-4
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: With triethylamine; In tetrahydrofuran; for 2h;

Reference yield:

: 1159735-55-3
(2S,5R)-2-tert-butyl-3-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-imidazolidin-4-one

: 1257638-06-4
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / 2 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

2.2: -10 - 0 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

3.2: 1.5 h / 50 °C

4.1: acetonitrile / 60 °C

5.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

6.1: tetrachloromethane; triethylamine; triphenylphosphine / acetonitrile / 2 h / 0 °C

6.2: 2 h / 70 °C

7.1: N-iodo-succinimide; pyridinium p-toluenesulfonate / dichloromethane / 1 h / Cooling with ice

8.1: sodium formate / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 20 °C

8.2: 20 h / 80 °C

9.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

10.1: triethylamine / tetrahydrofuran / 2 h

With 4-methyl-morpholine; tetrachloromethane; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; sodium formate; pyridinium p-toluenesulfonate; triethylamine; triphenylphosphine; sodium hydroxide; palladium diacetate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1159735-59-7
4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

: 1257638-06-4
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid {1-[1-(5-iodo-pyrimidin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

1.2: 1.5 h / 50 °C

2.1: acetonitrile / 60 °C

3.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

4.1: tetrachloromethane; triethylamine; triphenylphosphine / acetonitrile / 2 h / 0 °C

4.2: 2 h / 70 °C

5.1: N-iodo-succinimide; pyridinium p-toluenesulfonate / dichloromethane / 1 h / Cooling with ice

6.1: sodium formate / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 20 °C

6.2: 20 h / 80 °C

7.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

8.1: triethylamine / tetrahydrofuran / 2 h

With 4-methyl-morpholine; tetrachloromethane; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; sodium formate; pyridinium p-toluenesulfonate; triethylamine; triphenylphosphine; sodium hydroxide; palladium diacetate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;