(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

Base Information

Chemical Name:(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride
CAS No.:1159735-91-7
Molecular Formula:C₂₁H₁₂Cl₃FN₄O₂
Molecular Weight:477.709
Hs Code.:

Synonyms:(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

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Chemical Property of (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

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Technology Process of (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

There total 13 articles about (R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159735-71-3
(R)‐5‐(4‐cyanobenzyl)‐7‐(3,5‐dichloro‐4‐fluorophenyl)‐5‐methyl‐6‐oxo‐6,7‐dihydro‐5H‐imidazo[1,2‐a]imidazole‐3‐carboxylic acid

: 1159735-91-7
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1159735-59-7
4-[(2R,4R)-2-tert-butyl-1-(3,5-dichloro-4-fluoro-phenyl)-4-methyl-5-oxo-3-(2,2,2-trifluoro-acetyl)-imidazolidin-4-ylmethyl]-benzonitrile

: 1159735-91-7
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

1.2: 1.5 h / 50 °C

2.1: acetonitrile / 60 °C

3.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

4.1: tetrachloromethane; triethylamine; triphenylphosphine / acetonitrile / 2 h / 0 °C

4.2: 2 h / 70 °C

5.1: N-iodo-succinimide; pyridinium p-toluenesulfonate / dichloromethane / 1 h / Cooling with ice

6.1: sodium formate / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 20 °C

6.2: 20 h / 80 °C

7.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

With 4-methyl-morpholine; tetrachloromethane; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; sodium formate; pyridinium p-toluenesulfonate; triethylamine; triphenylphosphine; sodium hydroxide; palladium diacetate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1159735-51-9
[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 1159735-91-7
(R)-5-(4-cyano-benzyl)-7-(3,5-dichloro-4-fluoro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride / methanol; dichloromethane; water / 20 °C

2.1: pivalaldehyde / toluene / 22 h / 50 °C

3.1: triethylamine / 2 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -20 - -5 °C / Inert atmosphere

4.2: -10 - 0 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 6.5 h / 0 °C

5.2: 1.5 h / 50 °C

6.1: acetonitrile / 60 °C

7.1: 4-methyl-morpholine; potassium phosphate / dimethyl sulfoxide / 6 h / 65 °C

8.1: tetrachloromethane; triethylamine; triphenylphosphine / acetonitrile / 2 h / 0 °C

8.2: 2 h / 70 °C

9.1: N-iodo-succinimide; pyridinium p-toluenesulfonate / dichloromethane / 1 h / Cooling with ice

10.1: sodium formate / palladium diacetate / N,N-dimethyl-formamide / 0.75 h / 20 °C

10.2: 20 h / 80 °C

11.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

With 4-methyl-morpholine; hydrogenchloride; tetrachloromethane; potassium phosphate; N-iodo-succinimide; oxalyl dichloride; sodium formate; pyridinium p-toluenesulfonate; pivalaldehyde; triethylamine; triphenylphosphine; sodium hydroxide; palladium diacetate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;