(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

Base Information

Chemical Name:(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane
CAS No.:121649-10-3
Molecular Formula:C₂₂H₂₆F₃NO₆S
Molecular Weight:489.513
Hs Code.:

Synonyms:(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

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Chemical Property of (+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

Chemical Property:

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Technology Process of (+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

There total 9 articles about (+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 121649-06-7
(+/-)-1-<2,5-Dimethoxy-4-(2-hydroxyethyl)phenyl>-2-trifluoroacetamidopropane

: 98-59-9
p-toluenesulfonyl chloride

: 121649-10-3
(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

Guidance literature:: With pyridine; at 0 ℃; for 12h;
DOI:10.1016/S0040-4039(00)82391-6

Reference yield:

: 7417-19-8
2-(2,5-dimethoxyphenyl)ethanol

: 121649-10-3
(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) sodium hydride / 1.) THF, reflux, 16 h, 2.) THF, 0 deg C, 15 min, 20 deg C, 10 h

2: 24 percent / POCl₃ / 0.17 h / 100 °C

3: 70 percent / NH₄OAc / 2 h / 100 °C

4: 95 percent / aluminium hydride, 100percent H₂SO₄ / tetrahydrofuran / 0 deg C, 20 deg C 1 h followed 30 min reflux

5: 57 percent / TMSCl, Et₃N, TMSI / CH₂Cl₂; CHCl₃

6: 89 percent / Et₃N / diethyl ether / 1 h / 0 - 35 °C

7: 96 percent / pyridine / 12 h / 0 °C

With pyridine; aluminium hydride; chloro-trimethyl-silane; trimethylsilyl iodide; sulfuric acid; sodium hydride; triethylamine; trichlorophosphate; ammonium acetate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(00)82391-6

Reference yield:

: 16162-59-7
1,4-dimethoxy-2-(2-methoxyethyl)benzene

: 121649-10-3
(+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane

Guidance literature:: Multi-step reaction with 6 steps

1: 24 percent / POCl₃ / 0.17 h / 100 °C

2: 70 percent / NH₄OAc / 2 h / 100 °C

3: 95 percent / aluminium hydride, 100percent H₂SO₄ / tetrahydrofuran / 0 deg C, 20 deg C 1 h followed 30 min reflux

4: 57 percent / TMSCl, Et₃N, TMSI / CH₂Cl₂; CHCl₃

5: 89 percent / Et₃N / diethyl ether / 1 h / 0 - 35 °C

6: 96 percent / pyridine / 12 h / 0 °C

With pyridine; aluminium hydride; chloro-trimethyl-silane; trimethylsilyl iodide; sulfuric acid; triethylamine; trichlorophosphate; ammonium acetate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/S0040-4039(00)82391-6