(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

Base Information

Chemical Name:(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one
CAS No.:111934-07-7
Molecular Formula:C₄₁H₃₅NO₈
Molecular Weight:669.731
Hs Code.:

Synonyms:(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

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Chemical Property of (3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

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MSDS Files:: SDS file from LookChem

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Technology Process of (3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

There total 2 articles about (3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 111934-07-7
(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / tetrahydrofuran / 1) 0 deg C, 25 min; 2) 0 deg C, 20 min then 25 deg C, 25 min

2: ZnCl₂ / tetrahydrofuran / 4 h

With sodium hydride; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1021/ja00210a027

Reference yield:

: 50907-68-1
(trimethylsilyl)ketene acetal of dibenzyl malonate

: 111934-06-6
(3S,5S,6R)-4-(benzyloxycarbonyl)-3-bromo-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 111934-08-8
(3S,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

: 111934-07-7
(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

Guidance literature:: With zinc(II) chloride; In tetrahydrofuran; for 4h; Yield given. Yields of byproduct given;
DOI:10.1021/ja00210a027

Reference yield:

: 111934-07-7
(3R,5S,6R)-4-<(benzyloxy)carbonyl>-3-(O,O'-dibenzylmalonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-2H-1,4-oxazin-2-one

: 111934-05-5
D-β-carboxyaspartic acid

: 617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3
aspartic Acid

Guidance literature:: With hydrogenchloride; hydrogen; palladium dichloride; In tetrahydrofuran; for 27h; under 2068.6 Torr;
DOI:10.1021/ja00210a027