Technology Process of phenyl 3-fluoro-6-hydroxy-2-methyl-5-nitrobenzoate
There total 4 articles about phenyl 3-fluoro-6-hydroxy-2-methyl-5-nitrobenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutylammomium bromide; nitric acid;
In
water; 1,2-dichloro-ethane;
at 20 ℃;
DOI:10.1021/jm201467r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C
1.2: 2 h / -78 - 25 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C
2.2: 12 h / 25 °C
3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
4.1: nitric acid; tetrabutylammomium bromide / water; 1,2-dichloro-ethane / 19 h / 20 - 26 °C
With
oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; tetrabutylammomium bromide; sec.-butyllithium; nitric acid; boron tribromide;
In
tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C
1.2: 12 h / 25 °C
2.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
3.1: nitric acid; tetrabutylammomium bromide / water; 1,2-dichloro-ethane / 19 h / 20 - 26 °C
With
oxalyl dichloride; tetrabutylammomium bromide; nitric acid; boron tribromide;
In
dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
