(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

Base Information

Chemical Name:(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride
CAS No.:136677-02-6
Molecular Formula:C₁₅H₁₆N₄O₄*2ClH
Molecular Weight:389.238
Hs Code.:

Synonyms:(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

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Chemical Property of (S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

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Technology Process of (S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

There total 6 articles about (S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 114787-84-7
3-<(3-methyl-4-nitrophenyl)methyl>-L-histidine dihydrochloride

: 136677-02-6
(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

Guidance literature:: In water; 1.) RT, 30 min, 2.) reflux, 90 min;
DOI:10.1021/jm00115a014

Reference yield:

: 114787-84-7
3-<(3-methyl-4-nitrophenyl)methyl>-L-histidine dihydrochloride

: 136677-02-6
(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

Guidance literature:: With hydrogenchloride; formaldehyd;

Reference yield:

: 80866-75-7
3-methyl-4-nitrobenzyl alcohol

: 136677-02-6
(S)-4,5,6,7-tetrahydro-1-<(3-methyl-4-nitrophenyl)methyl>-1H-imidazo<4,5-c>pyridine-6-carboxylic acid dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: (iPr)2NEt / CH₂Cl₂ / 0.5 h / -75 °C

2: 1.) CH₂Cl₂, from -75 deg C to RT, 8 h, 2.) CH₂Cl₂, pH 7, 1.5 h

3: 100 percent / 6 N HCl / methanol / 1.5 h / Heating

4: 83 percent / H₂O / 1.) RT, 30 min, 2.) reflux, 90 min

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/jm00115a014