syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

Base Information

Chemical Name:syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol
CAS No.:250668-95-2
Molecular Formula:C₂₅H₃₅NO₃Si
Molecular Weight:425.643
Hs Code.:

Synonyms:syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

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Technology Process of syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

There total 4 articles about syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 7393-43-3
tetraallyl tin

: 250668-93-0
(2S)-3-phenyl-2-[N-(tert-butoxycarbonyl)amino]propanoyldimethylphenylsilane

: 250668-95-2
syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

: 250669-02-4
anti-(2S,3S)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo982501x

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 250668-95-2
syn-(2S,3R)-2-[N-(tert-butoxycarbonyl)amino]-3-dimethylphenylsilyl-1-phenyl-5-hexen-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / tetrahydrofuran / 0.5 h / 20 °C

2: 2.62 g / tetrahydrofuran / 0.5 h / -78 °C

3: 13 percent / scandium(III) triflate / CH₂Cl₂ / 24 h / 20 °C

With scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Addition;
DOI:10.1021/jo982501x