Technology Process of methyl 2,6-anhydro-3,4-di-O-benzyl-5-deoxy-5-nitro-D-lyxohex-5-enonate
There total 4 articles about methyl 2,6-anhydro-3,4-di-O-benzyl-5-deoxy-5-nitro-D-lyxohex-5-enonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2,6-anhydro-3,4-di-O-benzyl-5-deoxy-D-lyxohex-5-enonate;
With
nitro acetate;
In
water;
at -33 ℃;
for 1.5h;
Cooling with acetone-dry ice;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jo2002193
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dihydrogenphosphate; sodium hypochlorite; 2-methyl-but-2-ene; sodium chloride / water; tert-butyl alcohol / 2 h / 20 °C
2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: nitro acetate / water / 1.5 h / -33 °C / Cooling with acetone-dry ice; Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; nitro acetate; potassium hydrogencarbonate; sodium chloride;
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo2002193
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Dess-Martin periodane / dichloromethane / 20 °C
2.1: sodium dihydrogenphosphate; sodium hypochlorite; 2-methyl-but-2-ene; sodium chloride / water; tert-butyl alcohol / 2 h / 20 °C
3.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C
4.1: nitro acetate / water / 1.5 h / -33 °C / Cooling with acetone-dry ice; Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
With
sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; nitro acetate; potassium hydrogencarbonate; Dess-Martin periodane; sodium chloride;
In
dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo2002193
