SB1317

Base Information

• Chemical Name: SB1317
• CAS No.: 1204918-72-8
• Molecular Formula: C₂₃H₂₄N₄O
• Molecular Weight: 372.47
• Hs Code.: 2934999090
• Mol file: 1204918-72-8.mol

Synonyms:

Chemical Property of SB1317

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Zotiraciclib 99.96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: TG 02 is a cyclin dependent kinase inhibitors (CDK inhibitors) for the treatment of chronic lymphocytic leukemia.

Technology Process of SB1317

There total 23 articles about SB1317 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C25H28N4O (937271-61-9) → TG02 (1204918-72-8)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; trifluoroacetic acid; In dichloromethane; for 6h; Inert atmosphere; Heating;

DOI:10.1021/jm201112g

Reference yield:

3-[(allylmethylamino)methyl]phenylamine (937271-56-2) → TG02 (1204918-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; butan-1-ol / 12 h / 90 - 100 °C

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; trifluoroacetic acid / dichloromethane / 6 h / Inert atmosphere; Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; trifluoroacetic acid; In dichloromethane; water; butan-1-ol;

DOI:10.1021/jm201112g

Reference yield:

allylmethyl-(3-nitrobenzyl)amine (937271-55-1) → TG02 (1204918-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol; tin(II) chloride hydrate / dichloromethane / 0 - 20 °C

2: hydrogenchloride / water; butan-1-ol / 12 h / 90 - 100 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; trifluoroacetic acid / dichloromethane / 6 h / Inert atmosphere; Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; methanol; tin(II) chloride hydrate; trifluoroacetic acid; In dichloromethane; water; butan-1-ol;

DOI:10.1021/jm201112g

upstream raw materials:

3-(2-chloropyrimidine-4-yl)phenol

4-(3-(but-3-en-1-yloxy)phenyl)-2-chloropyrimidine

3-[(allylmethylamino)methyl]phenylamine

C₂₅H₂₈N₄O

Refernces

• 1、 William, Anthony D.,Lee, Angeline C.-H.. "Acid mediated ring closing metathesis: A powerful synthetic tool enabling the synthesis of clinical stage kinase inhibitors". . p. 142 - 145. Retrieved 2015/04/27.