methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

Base Information

Chemical Name:methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate
CAS No.:1428668-45-4
Molecular Formula:C₂₇H₂₅N₃O₃
Molecular Weight:439.514
Hs Code.:

Synonyms:methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

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Chemical Property of methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

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Technology Process of methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

There total 5 articles about methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1428668-35-2
C₂₀H₂₂ClN₃O₂

: 98-88-4
benzoyl chloride

: 1428668-45-4
methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 190 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c3ob27177c

Reference yield:

: 3970-35-2
2-chloro-3-nitrobezoic acid

: 1428668-45-4
methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

2: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / Reflux; Inert atmosphere

3: zinc; ammonium formate / methanol / 0.17 h / 20 °C / Inert atmosphere

4: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 190 °C / Inert atmosphere

With dmap; copper(l) iodide; 1,10-Phenanthroline; ammonium formate; magnesium sulfate; caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/c3ob27177c

Reference yield:

: 445466-21-7
methyl 3-amino-4-(isopentylamino)benzoate

: 1428668-45-4
methyl 1-(3-methylbutyl)-2-(2-phenyl-1,3-benzoxazol-7-yl)-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

2: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / Reflux; Inert atmosphere

3: zinc; ammonium formate / methanol / 0.17 h / 20 °C / Inert atmosphere

4: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 190 °C / Inert atmosphere

With dmap; copper(l) iodide; 1,10-Phenanthroline; ammonium formate; magnesium sulfate; caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/c3ob27177c