N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

Base Information

• Chemical Name: N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide
• CAS No.: 1422851-67-9
• Molecular Formula: C₁₈H₁₇ClFN₃O₂
• Molecular Weight: 361.803

Synonyms:N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

Chemical Property of N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

There total 20 articles about N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

C26H23ClFN3O4 → N1-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N2-(4-chloro-3-fluorophenyl)-oxalamide (1422851-67-9)

Guidance literature:

With methyl-phenyl-thioether; trifluoroacetic acid; at 70 ℃; for 1h;

Reference yield:

[(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate (1422851-70-4) → N1-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N2-(4-chloro-3-fluorophenyl)-oxalamide (1422851-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethyl acetate / 2.5 h / 20 °C

With sodium azide; palladium on activated charcoal; hydrogen; In dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/ml300407y

Reference yield:

N1-(4-chloro-3-fluorophenyl)-N2-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide (1422851-50-0) → N1-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N2-(4-chloro-3-fluorophenyl)-oxalamide (1422851-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: sodium azide / dimethyl sulfoxide / 3 h / 70 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / ethyl acetate / 2.5 h / 20 °C

With sodium azide; palladium on activated charcoal; hydrogen; triethylamine; In dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/ml300407y

upstream raw materials:

N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide

[(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate

1-indene

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate

Downstream raw materials:

(+)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1422851-67-9 N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send