1422851-70-4

Basic information

• Product Name: [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate
• Synonyms: [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate
• CAS NO: 1422851-70-4
• Molecular Weight: 440.88
• Mol File: 1422851-70-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate(1422851-70-4)
• EPA Substance Registry System: [(1R,2S)-1-{(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl}methyl] methanesulfonate(1422851-70-4)

Safety Data

• Hazardous Substances Data: 1422851-70-4(Hazardous Substances Data)

Upstream product

• 1422851-50-0 N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2S)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide 
• 124-63-0 methanesulfonyl chloride 
• 95-13-6 1-indene 
• 1226789-23-6 ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate 
• 135053-20-2 (1R,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylic acid 
• 55269-97-1 [(1R,2R)-1-amino-2,3-dihydro-1H-inden-2-yl] methanol 
• 1422851-66-8 N¹-(4-chloro-3-fluorophenyl)-N²-((1R,2R)-2-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)oxalamide 

Downstream Products

• 1422851-73-7 N¹-((1R,2R)-2-(azidomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl) oxalamide 
• 1422851-67-9 N¹-((1R,2R)-2-(aminomethyl)-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)-oxalamide 
• 1422851-31-7 (+)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt 
• 1422851-39-5 (-)-N¹-(4-chloro-3-fluorophenyl)-N²-(trans-2-(guanidinomethyl)indan-1-yl)oxalamide formate salt 

Relevant articles and documents

CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF

Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gpl20, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD- 556.